Heather Watson - the only British woman left in the Wimbledon singles draw - is out after losing to world number three Agniezka Radwanska.
The 20-year-old from Guernsey won just two games on centre court as Radwanska eased to a 6-0 6-2 victory. Watson was bidding to become the first British female in the last 16 since 1998.
2004 champion Maria Sharapova is safely through after beating Su-Wei Hsieh 6-1 6-4. The top seed will face German Sabine Lisicki in the fourth round.
In the men's draw, Roger Federer recovered from losing the first two sets to beat French 29th seed Julien Benneteau. Playing under a roof that had been shut all day on centre court, the six time champion looked like he could be heading for a third round exit similar to Rafael Nadal's the day before. However, Federer took advantage of an injury to Benneteau and secured the win 4-6 6-7 6-2 7-6 6-1.
Last year's champion Novak Djokovic overcame a first set loss to defeat Radek Stepanek 4-6 6-2 6-2 6-2, the day after one of his closest rivals Rafael Nadal crashed out of the competition.
The USA's Sam Querry beat 21-seed Milos Raonic and now faces Marin Cilic in the third round. The winner of that will play Andy Murray or his next opponent Marcos Baghdatis.
Vera Zvonareva's retirement through injury provided Kim Clijsters a place in the next round. The Belgian was already on top, however - the match 6-4 4-3 in her favour.