A teenage boy and his father were killed and his mother and younger sister were left fighting for their lives after a car crash, police said.
Ethan Sarkar, 14, was a passenger in the Golf which his 47-year-old father, Derek John Sarkar, was driving when it hit a car coming the other way on a bridge in the village of East Cowick, East Yorkshire.
The teenager's 44-year-old mother Karen and nine-year-old sister Abbie remain in a critical condition at Leeds General Infirmary after the incident at around 1:30pm on Saturday afternoon.
The driver of the other car, Sheila Stavert-Lee, aged 70, from Wigginton, near York, was also killed in the head-on collision on a bridge over the Aire and Calder Navigation canal.
Police have said initial investigations suggest the Volvo driven by Mrs Stavert-Lee was on the wrong side of the road at the time of the collision.
A Humberside Police spokeswoman said tonight: "It appears the Volvo had crossed on to the wrong side of the carriageway into the path of the oncoming Golf."
Three ambulances, two paramedic rapid response vehicles and two air ambulances were part of a huge emergency services operation alongside police and firefighters.
Cranes were brought in to lift the wreckage of the two vehicles from the bridge and the clear-up operation took more than seven hours.
Debbie Hinchliffe lives about 50 metres away. She explained how she ran to the cars to hear the sound of children screaming and found the elderly woman unconscious in the Volvo.
Mrs Hinchliffe said she hoped something was done about the road outside her house which has seen a number of crashes.
She said: "It was a shock - the severity of it. I was stood at my gate and I heard the crash. I ran to the scene. Two cars were written off.
"The old lady was unconscious and kids were screaming in the back of the other car. And I couldn't get anybody out. The car was going to catch fire with the old lady in.
"So I got in the car with her to turn the ignition off. I released her seatbelt and just stuck with her really. I couldn't do anything else."
Humberside Police have appealed for motorists who were driving on the A614 at the time to come forward.