Italian prosecutors have launched an appeal against the acquittal of Amanda Knox and her former boyfriend over the murder of British student Meredith Kercher.
A 112-page document has been lodged with the country's highest criminal court, more than four months after an appeals court threw out the convictions against Ms Knox, 24, and Raffaele Sollecito, 27.
Perugian prosecutor Giovanni Galati said he is "very convinced" the pair are responsible for the stabbing death of 21-year-old Ms Kercher , who shared an apartment with Knox in the university town of Perugia.
Mr Galati told reporters in Perugia that the appeals sentence must be thrown out, saying it was full of "omissions and many errors", news agency ANSA reported.
The prosecutors' appeal, which was expected, marks the third and final stage in the criminal case against Ms Knox and Mr Sollecito.
The two were found guilty in a lower court of killing Ms Kercher, in what prosecutors described as a sex-fuelled attack in 2007, and were sentenced to 26 years and 25 years respectively.
An appeals court then said the evidence did not hold up, freeing Ms Knox to return home to the United States after serving four years in prison.
Mr Sollecito lives in Italy.
His lawyer, Luca Maori, said the high court was expected to issue its decision towards the end of the year.
"We will write our brief to say it's a mistake," Mr Maori said.
The high court cannot hear new evidence, and will make its decision based on what has been submitted in earlier trials.
The fatal blow to the prosecution's case was a court-ordered DNA review in the appellate trial that discredited crucial genetic evidence used to convict Ms Knox and Mr Sollecito in 2009.
While clearing the pair, the appellate panel stopped short of saying what might have happened on the night of the murder.
A third defendant, Ivory Coast-born drifter Rudy Guede, was convicted in a separate trial of sexually assaulting and stabbing Ms Kercher.
His 16-year sentence, reduced in appeal from an initial 30 years, was upheld by Italy's highest court in 2010.


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