The former Bosnian Serb commander Ratko Mladic has been extradited to The Hague after Serbia's war crime court rejected his appeal.
The 69-year-old's lawyer and family have said that he is mentally unstable and too ill to stand trial.
The appeal, posted on Monday, was rejected within hours.
Serbain Justice Minister Snezana Malovic said: "Ratko Mladic has been extradited. That means he is in the plane en route to The Hague tribunal."
Mladic is charged with genocide in the 43-month siege of Sarajevo and the massacre of 8,000 Muslims in Srebrenica during the 1992-95 Bosnian War.
Doctors who assessed Mladic's health on Friday said the former war commander is fit enough to stand trial.
Mladic was allowed to meet family members and travel to the grave of his daughter Ana under heavy police guard.
Ana Mladic reportedly shot herself with her father's pistol after she read about his alleged crimes.