Large groups of young people were seen embracing and posing for photos in the city centre before the stricter rules were imposed at midnight.
Under Tier 3 measures in Greater Manchester, pubs and bars will be closed for an initial 28-day period unless they are serving substantial meals, along with casinos, bingo halls and bookies.
Police patrols could be seen talking to partygoers as they spilled out into Manchester city centre after last pints were pulled before the 10pm closing time.
Elsewhere staff started to pack up the empty alfresco drinking areas and slashed prices of their stock on another quiet night for business.
A mass EndSars protest, against police brutality in Nigeria, was also held in Piccadilly Gardens, at 8pm with protesters gathering for a candlelight vigil before the midnight deadline.
It is believed that about 2,000 of Greater Manchester's venues will be affected by the new rules.
These “wet pubs” will be forced to close their doors if they don't serve 'substantial meals' with their drinks
People gathered outside Impossible theatre and bar which proclaims “Andy Burnham: King of the North” a huge sign for its last night before being forced into temporary closure after “one restriction too many”.
Their management said in a statement: “There has rarely been a free seat in the venue since we re-opened but as soon as our city was threatened with tier 3 by ‘you know who’ we’ve used that time to decide its simply impossible to operate with the new restrictions."
Greater Manchester Police confirmed there was no major disorder or arrests last night despite online reports of people shouting in the town centre at 2am in the morning.
The Treasury's new package includes making the Job Support Scheme, which replaces the current furlough system, more generous and grants of £2,100 available for firms in Tier 2 areas of England.
Crucially for Greater Manchester pubs, many of which have been under equivalent restrictions or even tougher ones since the end of July, payments will be backdated to August.
In the hip Northern Quarter, Port Street Beer House said they were forced to close under the new restrictions.
The popular bar has said it needs to 'get rid' of as much beer as possible before it's wasted and slashed prices in half, with cask ale from as little as £1.75 a pint.
Underground Victorian drinking hole The Gas Lamp was also forced to close.
Announcing they would be selling cask beer for £2 a pint today, staff tweeted: “Right then people, you all know the score, Andy Burnham fought our corner but Boris just swanned in and took a dump right on all our doorsteps!”
Greater Manchester moved into the highest alert level , Tier 3, on Friday morning, and Wales will introduce its two-week "firebreak" lockdown at 6pm.