Tonight's scenes saw Louis' life left in danger when he was violently attacked, while Ange is still missing and Henrik began to unravel.
Here are the six biggest questions we've been left to ponder until next week:
1. Is Louis dead?
Another week, another shocking Holby cliffhanger and this time it's Louis McGerry we've been left to worry about.
Louis' life was left hanging in the balance when vengeful patient Vicky stabbed him in the closing moments of the episode.
Prior to that, Louis had been aiding Chloe in tracking down Ange, but his ordeal means she's now been left in the lurch.
Next week's scenes will see Louis's attack send shockwaves through the hospital as his colleagues desperately try to save him. But will he be okay?
2. And what's going on with Vicky?
After stabbing Louis, Vicky's vicious revenge plan also saw her steal his hospital badge, before leaving him to die. But it's not entirely clear why Vicky is so angry with him in the first place.
Given that the pair clearly share a history, Vicky's backstory will continue to be explored in upcoming episodes, but what is going on?
3. Will Chloe find Ange?
Chloe's mission to unravel Cameron's tangled web was obstructed when partner in crime Louis was attacked, and Ange's life is now very much hanging in the balance.
Terrified for her mum – and adamant that Cameron has got something to do with it – Chloe has been frantically trying to find Ange but to no avail.
Helpless, Ange desperately tried to fight her way to freedom tonight, but with a menacing Cameron never too far away, it's clear she's fighting a losing battle. Will anyone find Ange before it's too late?
4. What now for Reyhan?
Sahira was left devastated tonight when Reyhan's surgery went drastically wrong. Moments before the operation was due to start, Sahira had told Henrik that a serious allegation had been made against Reyhan and her husband wouldn't allow their children to see him as a result.
A shaken Henrik was forced to bury the information in order to perform the surgery but was so distracted that he ended up making a major mistake. As a consequence, Reyhan has been left in a coma, so what does the future hold for him now?
5. Will Henrik tell Sahira the truth?
Now aware that he wasn't Reyhan's only victim, the big question is whether Henrik will share this information with Sahira.
Max also questioned Henrik on his history with Sahira's father, but the moment was interrupted by the news that Reyhan had suffered a major bleed.
With Henrik clearly struggling to suppress his emotions, he was seen telling an unconscious Reyhan that he is "not sure he tried" to truly save him during the surgery. But will Henrik tell Sahira the truth? And will she support him if he does?
6. What happens next?
Next week's episode is another big one for Cameron as the walls finally start to close in. Meanwhile, the team battle to save Louis and Ange's fate is revealed.
Check back here tomorrow to get a full spoiler breakdown on next week's scenes.
Holby City continues on Tuesday, March 23 at 7.50pm on BBC One.
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