Wyn Jones was injured just eight minutes into the Lions’ 28-10 victory over Japan at Murrayfield on Saturday.
Jones suffered the injury while being cleared out of a ruck and was escorted from the pitch by medics, with head coach Warren Gatland set to name a replacement and new captain.
“His shoulder dislocated. We’re getting it scanned but it’s looking like we’ll have to replace him,” Gatland said.
“It’s very disappointing. He’s been around rugby long enough but he’ll be gutted.
“We need to call someone in, get them PCR tested and hopefully get them on the flight tomorrow.”