But fans will be able to enjoy a whole evening of match ups before the main event gets underway.
There is a packed undercard taking place in north London with a host of interesting encounters available to whet your appetite before the heavyweights get down to business.
The first fight of the night will get underway just after 6pm with the main event expected to start at roughly 10pm. Times will be updated throughout the evening.
Joe Cordina vs TBC (4 x 3 mins Super-Featherweight Contest)
The Welshman is set to open the bill after marking his professional debut with victory over Jose Aguilar as recently as April 23.
Cordina is the latest Team GB fighter to move into the paid ranks since appearing at the Rio Olympics.
Josh Kelly vs Faheem Khan (4 x 3 mins Super-Welterweight Contest)
Sunderland-based fighter Kelly faces Exeter's Faheem in only his second professional appearance.
The 23-year-old made his debut earlier in April and is relishing a chance to shine on the big stage.
Kelly said: "I’m on a learning curve and this is just another part of it.”
Lawrence Okolie vs Russell Henshaw (4 x 3 mins Cruiserweight Contest)
Okolie is the man many people will be tuning in early to see.
The Hackney cruiserweight has made a blistering start to his professional career and will be expected to make short work of opponent number three.
The bout is set to be a 'float', meaning Okolie could be ushered into the ring at relatively short notice.
Katie Taylor vs Nina Meinke (10 x 2 mins WBA Inter-Continental Lightweight Championship)
Taylor's fifth bout in as many months will see her take on unbeaten German Meinke.
Taylor won gold at London 2012 and is sure to get a roaring reception from the capital's crowd.
The winner will earn the right to fight Cecilia Comunales for the WBA world lightweight title.
Luke Campbell vs Darleys Perez (12 x 3 mins WBA World Lightweight Championship Eliminator)
Campbell has aspirations to fight at world level and will get an opportunity to do so if he is victorious under the arch.
The Yorkshireman said: "This is the fight of my career so far. I believe now that I'm ready for a shot at the world title."
Former world champion Perez, twice fought in Manchester against Anthony Crolla, drawing in their first contest before losing the second.
Scott Quigg vs Viorel Simon (12 x 3 mins IBF World Featherweight Championship Eliminator)
Quigg is in the frame for an IBF featherweight world title clash against Lee Selby if he beats Romanian-fighter Simion.
Quigg, who will have new trainer Freddie Roach in his corner for the first time, has lost just once in 35 career fights.
But the Scotsman's profile ha suffered since losing to Carl Frampton in February 2016 and he needs a big performance to get back on track.
- Quigg to win: 1/34
- Viorel to win: 10/1
- Draw: 33/1
Main event: Anthony Joshua vs Wladimir Klitschko
The top bout of the evening needs no introduction.
We're set to witness a classic case of youth against experience and student versus teacher as Joshua attempts to prove that 'Father Time' has caught up with Klitschko.
Tale of the tape (scroll over the interactive image below)
Carl Froch is convinced Joshua should not be seen as the 'odds-on favourite' but you will struggle to find many people supporting Dr. Steelhammer on Saturday.
- Joshua to win: 2/5
- Klitschko to win: 2/1
- Draw: 33/1
Odd correct as of April 28 6.30pm.