Manchester City beat Watford 3-1 on Tuesday evening in their third game in seven days as the traditional festive fixture pile-up concluded for the Premier League leaders.
Guardiola was able to welcome back star man Kevin De Bruyne after the Belgian was stretchered off against Crystal Palace three days ago but suffered no last damage.
But the former Barcelona and Bayern Munich head coach is not happy, insisting those in charge should "think about the artists."
He told BBC's Match of the Day: "We played really well. After dropping two points, we spoke about our reaction because big teams drop points but not too much.
"We made five changes from the last game but it's not our fault. I know here in England the show must go on, but that’s not normal guys. The big bosses should reflect that.
"We’re going to kill the players. The federations don’t think about the players but they have to. They play 11 months in a row. They have to protect them and play with quality and not quantity. We have to think about the artists. But I know it won’t happen.
"Watford scored because they have good players. We will review the action but people can not expect us to win 7-0 every time."