Arsene Wenger's side had to come from behind to secure a valuable point and similar levels of belief are likely to be required at Wembley.
The Gunners' faltering top-four bid has created a toxic atmosphere and falling short against Pep Guardiola's men will add another string to the bow of the 'Wenger Out' brigade.
But securing a third Cup final appearance in four years may just lead to additional support for the Frenchman as he attempts to guide the club towards silverware and, perhaps more crucially, a Champions League place.
Scroll down for Standard Sport's comprehensive preview...
Arsenal face Manchester City at Wembley Stadium, with kick-off scheduled for 3pm on Sunday, April 23.
TV AND LIVE ONLINE COVERAGE
The match will be televised live in the UK on BT Sport 1, with coverage starting at 2:30pm.
Alternatively, you can follow all the build-up and action from 2pm with Standard Sport’s London Football live blog. Enter your email address below to be informed when coverage begins.
Wenger opted to shake things up against Middlesbrough last time out, fielding a surprise three-man defensive system at Riverside Stadium.
That meant a total of six players were dropped, including Hector Bellerin and Theo Walcott, but it is unclear whether a similar approach will be adopted against City.
Arsenal have a number of injury problems here though, with David Ospina (back), Danny Welbeck (toe), Shkodran Mustafi and Lucas Perez (thigh) all missing while Jeff Reine-Adelaide (ankle) and Santi Cazorla (Achilles) will not play again this season.
Provisional squad: Cech, Martinez, Macey, Bellerin, Holding, Gabriel, Koscielny, Mertesacker, Monreal, Gibbs, Maitland-Niles, Coquelin, Xhaka, Ramsey, Oxlade-Chamberlain, Ozil, Walcott, Iwobi, Sanchez, Giroud.
Manchester City striker Gabriel Jesus could return after two months out with a broken foot.
Defender John Stones has been ruled out after failing to recover from the muscle injury which forced him out of last week's Premier League victory at Southampton.
With Claudio Bravo having featured in the last two Premier League games, Willy Caballero could return in goal if manager Pep Guardiola sticks to his usual cup rotation policy. Right-back Bacary Sagna (groin) is unlikely to return.
Provisional squad: Caballero, Bravo, Zabaleta, Navas, Kompany, Otamendi, Clichy, Kolarov, Toure, Fernando, Fernandinho, Delph, De Bruyne, Silva, Sterling, Sane, Nolito, Aguero, Jesus, Iheanacho.
Arsenal starting XI: Cech, Gabriel, Koscielny, Holding, Bellerin, Elneny, Xhaka, Monreal, Oxlade-Chamberlain, Ozil, Sanchez
Man City starting XI: Caballero, Navas, Kompany, Otamendi, Clichy, Fernandinho, Toure, De Bruyne, Silva, Sane, Aguero
BETTING ODDS (via 888 Sport)
- Arsenal to win in 90 mins: 5/2
- Man City to win in 90 mins: 3/4
- Arsenal to win after extra time: 20/1
- Man City to win after extra time: 12/1
- Arsenal to win on penalties: 16/1
- Man City to win on penalties: 14/1
Click here to place a bet. Odds correct as of April 21 at 9:30pm.