Even though the outcome of Sunday’s game is not expected to have a direct bearing on Wenger’s future, another defeat to a top-six rival after last week’s 2-0 loss at Tottenham would see the pressure ratchet up on the Frenchman even further.
That defeat at White Hart Lane has not entirely ended Arsenal’s challenge for a top four spot, going into the weekend they sit six points behind fourth-placed Manchester City with a game in hand.
But failure to beat a United side dogged by a string of injuries to key players, particularly in defence, would surely mean the end to Arsenal’s 20-year record of Champions League qualification. And Wenger has never bested Mourinho in the Premier League.
Scroll down for Standard Sport’s comprehensive preview…
Arsenal host Manchester United at the Emirates Stadium, with kick-off at 4pm on Sunday May 7.
TV AND LIVE ONLINE COVERAGE
The match will be televised live on Sky Sports 1, but you can follow coverage right here via our London Football live blog.
Can’t see the live blog? Click here to access our desktop site.
Arsenal are not believed to have suffered any new injuries from their bruising 2-0 defeat at White Hart Lane. But they are unlikely to see their squad swelled by the return of German centre-back Shkodran Mustafi - who is also expected to miss the visit to Southampton with a thigh injury - and is a doubt for the following game at Stoke.
Santi Cazorla remains a long-term absentee while David Ospina and Lucas Perez - both players whose long-term future at the Emirates is surrounded in doubt - continue to find themselves on the sidelines.
Wenger is expected to continue with the 3-4-2-1 he has deployed in his last four games despite finding his side outclassed at White Hart Lane in a system that they continue to struggle with.
Manchester United’s injury woes have been so severe that Mourinho joked after the draw with Swansea that his players “could walk to the toilet and break a leg” after he saw Luke Shaw and Eric Bailly depart through injury.
Shaw is out for the season and joins Zlatan Ibrahimovic, Marcos Rojo and Tim Fosu-Mensah on the sidelines, although Paul Pogba, Chris Smalling and Phil Jones return to the fold for United's Europa League semi-final first leg against Celta Vigo on Thursday.
Eric Bailly is "ready to play" after being forced with a muscle problem against Swansea, while Juan Mata is available to face Celta after returning to the bench on Sunday following a groin injury.
However, Mourinho hinted that he would consider fielding a weakened team against the Gunners with Europa glory now appearing to offer the most realistic chance of Champions League qualification.
Arsenal XI: Cech; Gabriel, Koscielny, Monreal; Oxlade-Chamberlain, Xhaka, Ramsey, Gibbs; Ozil, Sanchez; Giroud
Manchester United XI: De Gea; Valencia, Bailly, Blind, Darmian; Carrick, Herrera, Pogba; Mkhitaryan, Rashford, Martial
BETTING ODDS (via 888 Sport)
- Arsenal to win: 9/10
- Draw: 27/10
- Manchester United to win: 3/1
All odds correct as of 9pm on May 3. Click here to place a bet.