Having slipped away from the traditional big six, both sides have a point to prove.
Arsenal have eased an early crisis following a poor start to the season while Spurs have hit a slum after three straight wins have been followed by two defeats in the League.
Spurs made a flying start to the campaign but successive 3-0 losses against Crystal Palace and Chelsea have left new head coach Nuno Espirito Santo facing questions, while Harry Kane continues to struggle after his turbulent summer.
Following 1-0 wins over Norwich and Burnley, Arsenal further eased the scrutiny on Mikel Arteta by beating AFC Wimbledon in the Carabao Cup on Wednesday night and they go into the game at Emirates Stadium with a bit of momentum.
Date, kick-off time and venue
Arsenal vs Tottenham is scheduled for an 4:30pm BST kick-off at Emirates Stadium on Sunday.
Where to watch Arsenal vs Tottenham
TV channel: Sunday’s match will be televised on Sky Sports Premier League and Main Event, coverage starting at 4pm.
Live stream: Sky Sports subscribers will be able to watch the match online via SkyGo.
Arsenal vs Tottenham team news and lineups
Arsenal XI: Ramsdale, Tomiyasu, White, Gabriel, Tierney, Partey, Smith Rowe, Odegaard, Xhaka, Saka, Aubameyang
Subs: Leno, Lacazette, Maitland-Niles, Holding, Cedric, Pepe, Tavares, Sambi Lokonga, Martinelli
Tottenham XI: Lloris, Tanganga, Sanchez, Dier, Reguilon, Ndombele, Hojbjerg, Dele, Lucas Moura, Kane, Son
Subs: Romero, Gil, Emerson, Rodon, Lo Celso, Gollini, Skipp, Davies, Scarlett
Arsenal vs Tottenham prediction
The stakes are high for two managers who know the pressure on them will ramp up if things do not go their way. Neither can afford a defeat.
Head to head (h2h) history and results
Arsenal wins: 83
Spurs wins: 66
Betting odds and tips
Arsenal to win: 6/5
Tottenham to win: 23/10
Odds via Betfair (subject to change). Click here to find out more.