The striker has struggled for chances this season but, with Alexandre Lacazette and Pierre-Emerick Aubameyang both out, he could start at Emirates Stadium.
Arsenal will also have to cope without defenders David Luiz and Kieran Tierney, who are still struggling with knee issues.
Martin Odegaard, however, is back on the bench after recovering well from an ankle problem.
“They are all doing really well to be fair, they are a little bit ahead of schedule,” said Mikel Arteta.
“We don’t expect them for Everton I think, we have a doubt with Martin a little bit, let’s see how he is today in training. The rest will be out and get them back in the team as quick as possible.”
Arsenal predicted XI (4-2-3-1): Leno; Chambers, Holding, Mari, Xhaka; Partey, Ceballos; Saka, Smith Rowe, Pepe; Nketiah
Friday 8.00pm GMT, Sky Sports
Venue: Emirates Stadium
Referee: Jonathan Moss
Arsenal squad from: Leno, Runarsson, Ryan; Bellerin, Cedric, Chambers, Gabriel, Holding, Mari; Ceballos, Elneny, Odegaard, Partey, Saka, Smith Rowe, Xhaka; Balogun, Martinelli, Nelson, Nketiah, Pepe and Willian.
Doubts: Odegaard (ankle)
Injured: Aubameyang (malaria), Lacazette (hamstring), Luiz (knee) and Tierney (knee)