Given the tight turnaround - and the fact Arsenal’s season rests on the Europa League - Arteta has shuffled his pack for the trip to St. James' Park.
Hector Bellerin comes into the defence, while David Luiz makes his first start since recovering from a knee injury picked up in March.
Mohamed Elneny gets a rare start in midfield, alongside Dani Ceballos, who keeps his place given he is suspended for the second leg with Villarreal.
Up front, captain Pierre-Emerick Aubameyang starts after coming off the bench on Thursday night following his battle with malaria.
Arsenal starting XI (4-2-3-1): Ryan, Bellerin, Luiz, Gabriel, Xhaka, Elneny, Ceballos, Willian, Odegaard, Martinelli, Aubameyang.
Sunday 2.00pm GMT Sky Sports
Venue: St. James’ Park
Referee: Mike Dean
Arsenal squad from: Leno, Runarsson, Ryan; Bellerin, Cedric, Chambers, Gabriel, Holding, Luiz, Mari, Tierney; Ceballos, Elneny, Odegaard, Partey, Saka, Smith Rowe, Xhaka; Aubameyang, Balogun, Lacazette, Martinelli, Nelson, Nketiah, Pepe and Willian.
Doubts: Lacazette (hamstring), Tierney (knee)