Eddie Nketiah and Folarin Balogun both start for the Gunners, in what looks an exciting lineup.
Pablo Mari is out with Covid-19, with Ben White picked alongside Rob Holding. Cedric Soares and Nuno Tavares are starting as the full full-backs
In midfield, Albert Sambi Lokonga will miss out as he also has Covid, which means Mohamed Elneny plays, and Martin Odegaard starts in what looks to be a deeper role.
In attack, Pierre-Emerick Aubameyang is still unlikely to return and as such Nketiah gets rare along with Balogun.
Behind them, Nicolas Pepe comes in while Emile Smith Rowe starts after a run of successful cameos off the bench.
Arsenal XI: Leno, Cedric, White, Holding, Tavares, Elneny, Odegaard, Pepe, Smith Rowe, Nketiah, Balogun
Subs: Ramsdale, Tierney, Gabriel, Partey, Xhaka, Patino, Saka, Martinelli, Lacazette
Tuesday 7.45pm GMT, Sky Sports
Venue: Emirates Stadium
Referee: Simon Hooper
Arsenal squad from: Leno, Ramsdale, Okonkwo; Cedric, Chambers, Gabriel, Holding, Tavares, Tierney, Tomiyasu, White; Elneny, Maitland-Niles, Odegaard, Partey, Saka, Smith Rowe, Xhaka; Aubameyang, Balogun, Lacazette, Martinelli, Nketiah and Pepe.
Out: Kolasinac (ankle), Lokonga (Covid-19), Mari (Covid-19)