The explosion on Tuesday sent shockwaves through the city, destroying dozens of buildings and rendering as many as 250,000 people homeless.
Hospitals - already stretched from the ongoing coronavirus pandemic - are currently inundated with the wounded, while rescue workers continue to search for scores of people still missing following the blast.
The crisis comes as Lebanon already faces the perils of a rising Covid-19 caseload and a major economic collapse.
So, here's how you can help:
Donate to charities
A number of charities are working to help the victims of the blast.
Several of these have set up crowdfunding pages as they seek to marshal the necessary resources to support their efforts. Below is a list of some of the major charities appealing for donations:
Non-profit organisation Impact Lebanon has set up a JustGiving page in order to raise money for its disaster relief efforts. Donations can be made here.
Lebanese Red Cross
The Lebanese Red Cross is a humanitarian organisation and serves as an auxiliary team to the medical service of the Lebanese Army. Donations to the organisation can be made here.
Lebanese Food Bank
The Lebanese Food Bank provides food to families and individuals in need of supplies. Donations to the charity can be made here.
Assist local NGOs
Lebanese volunteers, charity workers and activists have built a crowd-sourced list of charities, local NGOs and response efforts in the wake of the explosion.
The resource, which advertises where people can make donations, sign petitions and engage with volunteer work, can be found here.
The Lebanese Red Cross has issued an urgent call for blood donations from all blood types following the blast.
The charity has asked anyone in Lebanon fit and able to do so to consider making a donation at blood transfusion centres dotted throughout the country.
Help locate victims
An Instagram account dedicated to helping locate those missing and believed to be victims of Tuesday's blasts has been setup.
The @locatevictimsbeirut account has been posting images of likely victims that are reported to have been separated from their friends and family.
Instagram users are able to share the posts, and potentially help reunite people with their loved ones.
The account can be found here.