Kaley, who hit the big time with her role as Penny in the sitcom, is currently basking in the glow of an Emmy nomination, after she was announced as a contender for Outstanding Lead Actress in a Comedy Series.
As well as bagging a nomination for her part as Cassie Bowden in The Flight Attendant, Kaley – who executive produced the dramedy – is also celebrating the series' eight other nominations.
Some of her former Big Bang co-stars are too, with both Kunal Nayyar and Laura Spencer (AKA Raj Koothrappali and Emily Sweeney) congratulating Kaley on social media.
The Flight Attendant's Michelle Gomez, Merle Dandridge and Griffin Matthews also celebrated Kaley's nomination, with Michelle writing on Kaley's latest Instagram post: "This is absolutely 100% deserved."
Merle Dandridge agreed, adding: "This is so deserved! Go Kaley!"
Following the Emmys' nomination ceremony, Kaley thanked her fans and peers for their support. "I have never done this for an accolade," she said in an emotional clip.
"I've been doing this for 30 years because I love being an actor, and so to get gifted with this nomination and this moment… there's so many people involved. So I'm gonna enjoy it, I'm so grateful. Thank you so much!"
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