The Seasiders last victory came in this competition earlier in the month, as Jake Beesley scored a brace in a 2-0 victory over Derby County.
Since then, they have gone four games without scoring.
Neil Crichley has made a number of changes from the 3-0 defeat to Lincoln City at the weekend.
O’Donnell, Pennington, Lyons, Virtue, Weir, Thompson and Carey all come into the starting 11.
Here is the full team: Richard O’Donnell, Matthew Pennington, Marvin Ekpiteta, Callum Connolly, Andy Lyons, Matty Virtue, Kenny Dougall, Jensen Weir, Dominic Thompson, Sonny Carey, Jake Beesley.
Substitutions: Dan Grimshaw, James Husband, Olly Casey, Douglas Tharme, Tashan Oakley-Booth, Albie Morgan, CJ Hamilton, Rob Apter, Owen Dale.