The series stars BAFTA-nominated actor Samson Kayo and Golden Globe-nominated actor Jane Horrocks.
Kayo and Horrocks play Maleek and Wendy, a pair of paramedics who are partnered up to save lifes, alongside their ambulance station colleagues in South London.
Both Kayo and Horrocks will be reprising their roles in the new season, with Lucy Punch (Motherland), Julian Barratt (Mighty Boosh), Adrian Scarborough (Gavin and Stacey), Aasiya Shah (Raised by Wolves), Kevin Garry (Ted Lasso) and Sam Campbell (Stath Lets Flats) also returning.
Katherine Kelly (Innocent) and Nathan Foad (Our Flag Means Death) will be new additions to the cast next season.
Bloods will air on Sky Comedy and streaming service Now in 2022, dropping on two different occasions.
Previously speaking exclusively to Digital Spy, Kayo said that he wants to explore more of Maleek and Wendy's lives in the new episodes.
He explained: "There are so many places we could go with this show. It'd be so nice to explore other characters, as well as what happens in Wendy and Maleek's lives. To just push that button and stick on those blue lights again would be amazing."
Kayo also said that working with Horrocks, of Absolutely Fabulous fame, was great as she is a "national treasure".
The relationship between Maleek and Wendy is interesting because they're "from different walks of life" but they each serve as a "therapist for the other."
"They both teach each other. They're both learning about each other's cultures in this one ambulance cab. I think it's beautiful to see, especially because we both had no idea that we would click so much," Kayo added.
The show was created by Kayo and Nathan Byron, and was inspired by Kayo's real-life experience as an ambulance support driver. He was originally going to train to be a paramedic but then stumbled into acting instead.
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