With Chelsea seeking to restore their seven-point advantage at the top of the table after Tottenham's 4-0 win over Watford earlier in the day, Matic starts to add more cover in central midfield.
Fabregas - who celebrated the birth on his third child this week - is on the bench alongside the likes of Kurt Zouma, Willian and Michy Batshuayi, while Pedro starts in attack alongside Eden Hazard and Diego Costa.
Striker Costa retains his place despite a recent goal drought, with Conte keeping his faith in the Spaniard to deliver the goals needed to fire the Blues to the title.
Wing-back Moses has recovered from a calf injury to start on the right flank, while the Blues will be wary as in-form Benik Afobe and Joshua King lead the line for Bournemouth.
Bournemouth starting XI: Smith, Francis, Cook, Daniels; Fraser, Arter, Wilshere, Pugh; King, Afobe
Subs: Allsop, Cargill, Ibe, Mousett, Gradel, B.Smith, L.Cook
Chelsea starting XI: Courtois; Azpilicueta, David Luiz, Cahill (c); Moses, Kante, Matic, Alonso; Pedro, Diego Costa, Hazard
Subs: Begovic, Terry, Zouma, Chalobah, Fabregas, Willian, Batshuayi