Mohamed Bin Hammam has retired from football, and has also been banned for life by Fifa, the governing body has confirmed.
The Qatari ran for the 2011 Fifa presidency, but was soon embroiled in a corruption scandal, and was given his first suspension by the organisation.
That was later overturned by the Court of Arbitration for Sport (CAS), but the governing body opened up a further investigation into his activities, and the 63-year-old has now chosen to end his career in the game.
"Mr Mohamed Bin Hammam, Fifa Executive Committee member and AFC president, has resigned from all his positions in football with immediate effect and will never be active in organised football again," a statement read.
"This results from a resignation letter of Mr Bin Hammam addressed to Fifa and AFC dated on 15 December 2012.
"In view of the fact that under the new Fifa Code of Ethics, the FIFA Ethics Committee remains competent to render a decision even if a person resigns, the Adjudicatory Chamber decided to ban Mohamed Bin Hammam from all football-related activity for life.
"This life ban is based on the final report of Michael J. Garcia, Chairman of the Investigatory Chamber of the FIFA Ethics Committee.
"That report showed repeated violations of Article 19 (Conflict of Interest) of the FIFA Code of Ethics, edition 2012, of Mohamed Bin Hammam during his terms as AFC President and as member of the FIFA Executive Committee in the years 2008 to 2011, which justified a life-long ban from all football related activity."
During his time in football, Bin Hammam acted as president of the AFC between 2002 and 2011.