Event organisers said on Monday it was making the move to “be as inclusive as possible”.
Performers will now be in the running for artist of the year or international artist of the year at the annual ceremony.
The next Brit Awards is due to take place on February 8, 2022.
The ceremony’s chair Tom March said: “It is important that The BRITs continue to evolve and aim to be as inclusive as possible.
“It feels completely the right time to celebrate the achievements of artists for the music that they create, and the work that they do, irrespective of gender.”
The Brits is following in the footsteps of other awards shows or events that have removed gender classifications.
In September, the San Sebastian Film Festival handed out its first ever gender-neutral acting award, for best leading performance, to joint winners Jessica Chastain and Flora Ofelia Hofmann Lindahl.
Next year’s Brit Awards, the 42nd edition of the awards show, will also extend nominations to featured artists in the coveted song of the year category.
Until now, only lead artists or named collaborators were recognised as nominees for the prize.
Four new genre awards will also be introduced to showcase a range of music styles: alternative/rock act, hip-hop/grime/rap act, dance act and pop/R’n’B act.
All four will be voted for by the public.
British comedian Mo Gilligan will host the show, while artistic team Block9 will help with the design.
He said: “It’s an absolute privilege to host the 2022 Brit Awards. I’m truly honoured to be asked.”
Clara Amfo, 37, and Maya Jama, 27, will also return to hosting duties and will front The Brits Are Coming nominations show and Brits Red Carpet show.
“The Brit Awards are not just a celebration of British music, they are a reflection of British culture,” said Geoff Taylor, chief executive of the British Phonographic Industry and Brit Awards.
“The changes we are making for the 2022 show should mean more new fans, more engagement and a bigger global platform than ever for our amazing artists.”