Sean Dyche's side sit 13th in the table almost purely down to their superb home record, with the Clarets picking up 29 of their 32 points this season at Turf Moor - including a recent 1-1 draw with table-toppers Chelsea.
Burnley are not safe from relegation yet with just eight points separating them from the drop zone, and are winless in their last seven league games.
Tottenham have won seven of their last 10 as they look to tighten their grip on second place, but Turf Moor could prove an unforgiving ground this weekend - particularly without the injured Harry Kane.
Scroll down for Standard Sport's comprehensive preview....
Burnley host Spurs at Turf Moor with kick-off scheduled for 3pm on Saturday, April 1.
TV AND LIVE ONLINE COVERAGE
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Vincent Janssen is struggling to be fit for Tottenham's Premier League game at Burnley on Saturday.
Janssen has a chest infection and will be assessed ahead of the match, while Harry Kane (ankle), Danny Rose (knee) and Erik Lamela (hip) are all ruled out.
Son Heung-min played 90 minutes for South Korea against Syria in Seoul on Tuesday but the striker will be back in time to be available.
Provisional squad: Lloris, Vorm, Lopez, Davies, Alderweireld, Vertonghen, Dier, Carter-Vickers, Wimmer, Walker, Trippier, Wanyama, Winks, Dembele, Eriksen, Alli, Sissoko, Onomah, Son, Janssen.
Burnley are still waiting on Johann Berg Gudmundsson's return to fitness but Steven Defour may make the bench against Tottenham.
Defour has been involved in first-team training following hamstring trouble but is not considered ready for the starting XI.
Gudmundsson (knee ligaments) is further away from a comeback and Dean Marney is out for the season.
Provisional squad: Heaton, Robinson, Pope, Lowton, Keane, Mee, Long, Ward, Darikwa, Tarkowski, Brady, Barton, Flanagan, Boyd, Hendrick, Westwood, Arfield, Vokes, Gray, Agyei.
Burnley starting XI: Heaton, Lowton, Keane, Mee, Ward, Boyd, Barton, Hendrick, Arfield, Barnes, Gray
Spurs starting XI: Lloris; Dier, Alderweireld, Vertonghen; Walker, Wanyama, Dembele, Davies; Eriksen, Alli; Son
BETTING ODDS (via 888 Sport)
- Burnley to win: 23/5
- Spurs to win: 13/20
- Draw: 29/10
Click here to place a bet. Odds correct as of April 1 at 9.15am.