Medics have called for breast cancer surgery guidelines to be revisited to make sure women have the best chance of staying healthy.
Experts from the University of Manchester said removing a small amount of non-cancerous tissue next to a tumour can reduce the risk of cancer returning.
After analysis of data on 68 studies on 112,140 cancer patients, they found removing more than 1mm of non-cancerous tissue from the edge of an excised tumour is associated with a lower risk of cancer returning.
Researchers said a previous study showed 21% of women in the UK had surgical margins of less than 1mm.
“Surgeons should aim to achieve a minimum clear margin of at least 1mm,” the academics wrote in The BMJ.
“On the basis of current evidence, international guidelines should be revised.”
This has major clinical implications for the surgical management of breast cancer and current international guidelines need revision to account for these findings
Professor Nigel Bundred
“If you remove a tumour but cancer cells remain present or close to the edges, the risk of disease returning is increased,” said lead author professor Nigel Bundred, a clinical scientist from the University of Manchester.
“That is why increased surgical focus on adequacy of margin excision would improve breast cancer survival worldwide.”
He added: “Our analysis leaves us confident that inadequate margin width is associated with higher risks of distant recurrence (where the cancer has spread to another part of the body) and breast cancer mortality even after adjuvant chemotherapy, as well as increased recurrence around the original surgical site.
“That has major clinical implications for the surgical management of breast cancer and current international guidelines need revision to account for these findings.”7
Commenting on the study, Jane Murphy, senior clinical nurse specialist at the charity Breast Cancer Now, said: “With around 55,000 women and 370 men receiving a breast cancer diagnosis each year in the UK, it’s crucial that everyone receives the treatment most effective and suitable for them to reduce the risk of cancer returning or spreading.
“This analysis adds to what we already know about the importance of ensuring a small amount of healthy tissue surrounding the tumour is removed during breast-conserving surgery and concludes that a minimum clear margin of at least 1mm should be achieved.
“This evidence can now be considered within current clinical practice and should be discussed as part of the patient’s treatment.
“Anyone affected by breast cancer seeking information and support can speak to our expert nurses by calling our free confidential helpline on 0808 800 6000.”