Antonio Conte's Blues lead Tottenham by 10 points with just 10 games remaining, and seven victories will ensure the Italian coach lifts the title in his debut season in England.
Sam Allardyce is busy thinking about the other end of the table as Palace fight for their top-flight survival, though the Eagles have been in fine form of late.
Palace have won their last three league games without conceding a goal to climb four points clear of the relegation zone, and Allardyce will be in no mood to see his streak end at the hands of Conte's title favourites.
Scroll down for Standard Sport's comprehensive preview....
Chelsea host Crystal Palace at Stamford Bridge with kick-off scheduled for 3pm on Saturday, April 1.
TV AND LIVE ONLINE COVERAGE
The match will not be televised live in the UK. Alternatively, you can follow all the build-up and action from 2pm with Standard Sport’s London Football live blog. Enter your email address below to be informed when coverage begins.
Can't see the live blog? Click here for the desktop version.
Eden Hazard is expected to recover from a calf injury but Chelsea could opt to leave him out of Saturday's clash with Crystal Palace ahead of Manchester City visiting on Wednesday.
Head coach Antonio Conte says he has a number of fitness issues to assess ahead of kick-off and goalkeeper Thibaut Courtois (hip) returned to training on Thursday.
Striker Diego Costa shrugged off a foot and ankle problem when on international duty with Spain, while Victor Moses (calf) is a doubt, but John Terry is back in contention.
Provisional squad: Courtois, Begovic, Fabregas, Zouma, Alonso, Kante, Hazard, Loftus-Cheek, Moses, Pedro, Costa, Matic, Willian, Batshuayi, Cahill, Terry, Azpilicueta, Chalobah, Luiz, Eduardo, Aina, Ake.
Crystal Palace will remain without Patrick van Aanholt when on Saturday they visit Chelsea in the Premier League.
The Dutchman is recovering from an ankle injury and could be joined as an absentee by Fraizer Campbell, who has a knock, and James McArthur, who is suffering from back spasms.
Mathieu Flamini could again be available having returned to training. Connor Wickham and Pape Souare, meanwhile, remain long-term absentees.
Team from: Hennessey, Mandanda, Speroni, Ward, Tomkins, Sakho, Dann, Delaney, Schlupp, Kelly, Flamini, McArthur, Ledley, Cabaye, Milivojevic, Puncheon, Townsend, Zaha, Benteke, Sako, Lee, Remy.
Chelsea starting XI: Courtois; Azpilicueta, Luiz, Cahill; Moses, Kante, Fabregas, Alonso; Willian, Costa, Pedro
Palace starting XI: Hennessey, Ward, Tomkins, Sakho, Schlupp, Cabaye, Milivojevic, Zaha, Puncheon, Townsend, Benteke
BETTING ODDS (via 888 Sport)
- Chelsea to win: 33/100
- Palace to win: 10/1
- Draw: 41/10
Click here to place a bet. Odds correct as of April 1 at 9.30am.