The 2-1 loss to Palace at Stamford Bridge allowed Tottenham to cut Chelsea's lead at the top to seven points with both the top two sides still facing nine games before the end of the campaign.
City are a further four points points back in fourth and would give their slender title hopes a lift by inflicting a second straight defeat on the Blues.
Scroll down for Standard Sport's comprehensive preview...
Chelsea host Manchester City at Stamford Bridge with kick-off scheduled for 8pm on Wednesday, April 5.
TV AND LIVE ONLINE COVERAGE
The match will be televised live on BT Sport 1, with coverage starting from 7.15pm. Alternatively, you can follow all the build-up and action from 2pm with Standard Sport’s London Football live blog. Enter your email address below to be informed when coverage begins.
Thibaut Courtois, Eden Hazard and Diego Costa are fit after coming through Saturday's defeat to Crystal Palace following fitness scares.
David Luiz continues to play through the pain of a knee injury, while Victor Moses faces a late test after missing the Palace loss. Pedro is likely to deputise if the wing-back is again deemed unable to feature.
City are without Bacary Sagna, who is injured, but Pablo Zabaleta is expected to return at right-back after missing Sunday's draw with Arsenal.
Chelsea starting XI: Courtois; Azpilicueta, Luiz, Cahill; Moses, Kante, Fabregas, Alonso; Hazard, Costa, Pedro
Manchester City starting XI: Caballero, Zabaleta, Stones, Otamendi, Clichy, Fernandinho, Sterling, De Bruyne, Silva, Sane, Aguero
BETTING ODDS (via 888 Sport)
Chelsea to win: 13/10
City to win: 21/10
Click here to place a bet. Odds correct as of April 2 at 6pm.