Antonio Conte's Blues are clear at the top of the Premier League, and the Italian coach will be eyeing FA Cup glory in a bid to complete the Double in his debut season in England.
Jose Mourinho has endured a more difficult league campaign at Old Trafford after being sacked by Chelsea last season, but has already won his first silverware with United at Wembley after guiding the Red Devils to an EFL Cup triumph in February.
United face a tough task to reach the last four of the FA Cup - especially having lost 4-0 here in the league earlier this term - and Zlatan Ibrahimovic's suspension will only serve to bolster Conte's hopes of a trophy-laden start to life in west London.
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Chelsea host Manchester United at Stamford Bridge with kick-off scheduled for 8pm on Monday, March 13.
TV AND LIVE ONLINE COVERAGE
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Zlatan Ibrahimovic's three-match ban for elbowing Tyrone Mings means United head into Monday's game without their top scorer.
The 35-year-old's absence will likely mean a rare chance for Marcus Rashford to lead the line, with the young striker hoping to impress Mourinho after playing a bit-part role this season.
Bastian Schweinsteiger is a doubt with a muscle injury - though the German would have had little chance of starting anyway - while Henrikh Mkhitaryan should be fit for the match.
Chelsea have no fresh injury or suspension concerns, meaning Conte is likely to stick with a first-choice XI with no European football to worry about on the horizon.
Chelsea starting XI: Courtois; Azpilicueta, Luiz, Cahill; Moses, Kante, Matic, Alonso; Pedro, Costa, Hazard
Man United starting XI: De Gea; Valencia, Smalling, Jones, Rojo; Pogba, Herrera; Mata, Mkhitaryan, Martial; Rashford
BETTING ODDS (via 888 Sport)
- Chelsea to win: 22/25
- United to win: 17/5
- Draw: 51/20
Click here to place a bet. Odds correct as of March 7 at 5pm.