Two losses in their previous four league games as seen the Blues' lead at the top cut to four points, while Tottenham's club-record seven Premier League wins on the trot sees them boosted by superior momentum.
The two teams traded wins on home ground in the league earlier this season, Chelsea's 2-1 win at Stamford Bridge followed by Tottenham 2-0 victory at White Hart Lane in January, and have similarly equal records in the FA Cup, with the Blues boasting five wins to Spurs' four.
The last time Chelsea and Tottenham met in the FA Cup, the north Londoners were brushed aside in a 5-1 defeat, which was marred by a controversial goal-line decision, five years ago.
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Chelsea and Tottenham meet at Wembley Stadium in the FA Cup semi-final with kick-off scheduled for 5.15pm on Saturday, April 22.
TV AND LIVE ONLINE COVERAGE
The match will be televised live on BBC One, with coverage starting from 4.50pm. Alternatively, you can follow all the build-up and action from 4.15pm with Standard Sport’s London Football live blog. Enter your email address below to be informed when coverage begins.
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Thibaut Courtois (ankle) and Marcos Alonso (ill) both missed Sunday's 2-0 loss at Manchester United but are expected to be fit to line up at Wembley.
Otherwise, Antonio Conte has a fully fit squad to work with ahead of the facing what he recently described as "the best team in England".
Mauricio Pochettino has no fresh injury concerns as Harry Kane came through his first start in five weeks unscathed against Bournemouth and Victor Wanyama returned from the bench.
The Argentine will now have to decide whether to go with the three-man defence used in the win at White Hart Lane earlier in the league, or drop Eric Dier in favour of Wanyama.
Chelsea starting XI: Courtois; Azpilicueta, Luiz, Cahill; Moses, Kante, Matic, Alonso; Pedro, Hazard; Costa
Tottenham starting XI: Lloris; Walker, Alderweireld, Vertonghen, Davies; Dembele, Wanyama; Eriksen, Alli, Son; Kane
BETTING ODDS (via 888 Sport)
- Chelsea to win in 90 mins: 7/5
- Tottenham to win in 90 mins: 8/5
- Chelsea to win after extra time: 14/1
- Tottenham to win after extra time: 15/1
- Chelsea to win on penalties: 10/1
- Tottenham to win on penalties: 11/1
Click here to place a bet. Odds correct as of April 17 at 5pm.