The Blues remain four points clear of sole title rivals Tottenham with both sides facing four games before the end of the campaign.
Antonio Conte's men host Middlesbrough before travelling to West Brom, and end the campaign with home matches against Watford and Sunderland.
Meanwhile, Tottenham visit West Ham before the final League game at White Hart Lane against Manchester United. Mauricio Pochettino's side then end the season with trips to champions Leicester and relegation-battling Hull.
Below, we look at the various possible outcomes in the Premier League title race
If Tottenham lose at West Ham on Friday, Chelsea can secure the title as early as Friday, May 12 if they defeat both Middlesbrough and West Brom.
After the match at the London Stadium, the Blues have two League fixtures before Spurs play again and can build an unassailable 10-point lead at the top if Mauricio Pochettino's men are defeated at West Ham.
However, if Chelsea do not collect maximum points from games against Boro and West Brom, the title race will remain open regardless of Tottenham's result at West Ham.
HOW JOSE MOURINHO CAN HAND CHELSEA THE TITLE
Mourinho could yet have a major say in his former club's title push. The 54-year-old led the Blues to three Premier League crowns across two spells at Stamford Bridge and could indirectly hand them another title.
If Tottenham beat West Ham and Chelsea maintain their winning habit in forthcoming games against Middlesbrough and West Brom, Mourinho's Manchester United would end Tottenham's title bid with victory in the last ever game at White Hart Lane.
If Pochettino's men draw against the Hammers and Chelsea string together successive wins, Tottenham would need to win against United to maintain their title push.
And Mourinho's United could even hand Chelsea the title if the Blues fail to record wins against both Middlesbrough and West Brom. If Chelsea pick up four points from those fixtures and Spurs don't get maximum points at West Ham, defeat to Mourinho's men would end Tottenham's trophy charge.
If Tottenham lose to West Ham and Chelsea collect four points from their next two games, Mourinho's United would only need a draw at the Lane to decide the title.
Finally, if Chelsea are shocked by one of Middlesbrough or West Brom and collect just three points from those fixtures, Manchester United can still have a decisive say by winning at Tottenham if Spurs also suffer defeat at West Ham.
HOW CHELSEA CAN WIN IF SPURS KEEP UP THE PACE
If Tottenham maintain their winning run, they will end the season on 89 points. Chelsea, currently on 81 points, would therefore win the league with three victories from their final four games. Their earliest opportunity to reach 90 points and be certain of title success is on Monday, May 15 at home to Watford.
Two wins and two draws in their final four fixtures would see Chelsea reach 89 points, though their goal difference is currently inferior to Tottenham's and Conte's men would likely lose out on the league crown.
LEICESTER REPAY THE FAVOUR
Another scenario could see Leicester end Tottenham's title bid and crown Chelsea champions, in much the same way Guus Hiddink's Chelsea held Spurs to hand the Foxes a first-ever top-flight trophy last year.
As explained above, if Chelsea win their next three games they will wrap up the title before Spurs travel to Leicester, but if Conte's side drop points the race could remain on.
Two wins and a draw from Chelsea's next three would leave Tottenham needing victory at the King Power Stadium to keep their silverware hopes alive, providing Spurs beat both West Ham and Manchester United. If Chelsea win two and lose one, Spurs would need to avoid defeat at Leicester, but again they must win at West Ham and against United for this scenario to play out.
If Chelsea fail to win two of their next three, Tottenham would go top if they extended their winning Premier League run to 12 games with victory at Leicester.
HOW TOTTENHAM CAN WIN THE TITLE
Spurs need Chelsea to drop at least four points from their remaining four fixtures. As such, two wins and two draws from Conte's side would allow Spurs the chance to win the title on goal difference.
Tottenham also need a perfect run-in if Chelsea gather seven points from their final four.
If Chelsea win six points from their last four, Tottenham need three wins and a draw, while just three wins would likely see Tottenham edge it on goal difference if Chelsea only get five points.
One win and a draw for the Blues would leave Spurs needing a minimum of two wins and two draws.
If Chelsea win just once during their run-in, losing three, Tottenham would likely win the league on goal difference with just two wins and a draw.
Meanwhile, Tottenham would only need two victories to secure the title if Chelsea have a miserable run-in and pick up one or two points.
If Chelsea lose all four of their remaining games, Tottenham would win the league with a win and a draw from their final four.