Mudryk has been dealing with a muscle injury of late but is back in full training and now returns to the matchday squad.
Pochettino, though, remains without seven players with Christopher Nkunku, Romeo Lavia, Ben Chilwell, Trevoh Chalobah, Armando Broja, Wesley Fofana and Carney Chukwuemeka all still sidelined.
Chelsea will continue with Robert Sanchez in goal but have options in defence as players return from injury.
Club captain James starts again with Thiago Silva, Levi Colwill and Axel Disasi in the back four.
A settled central midfield three of Conor Gallagher, Enzo Fernandez and Moises Caicedo continues.
The front three is Raheem Sterling, Palmer and Nicolas Jackson. Broja was a minor doubt for this game and doesn't make the bench.
Chelsea XI: Sanchez, James, Disasi, Thiago Silva, Colwill, Caicedo, Fernandez, Palmer, Gallagher, Sterling, Jackson
Subs: Cucurella, Badiashile, Mudryk, Madueke, Ugochukwu, Gusto, Petrovic, Maatsen, Deivid Washington
Injured: Nkunku, Lavia, Chilwell, Chalobah, Fofana, Chukwuemeka, Broja
Time and date: 8pm GMT on Monday November 6, 2023
Venue: Tottenham Hotspur Stadium