Pulisic is an injury doubt after he came off in the second half of Sunday’s 1-0 FA Cup win at Leicester with a tight calf and faces a late fitness test.
Lampard will also make a late decision on Andreas Christensen so Kurt Zouma could continue alongside Antonio Rudiger in the centre of defence.
Chelsea manager Lampard was unhappy with his side’s first-half display against Leicester and Ross Barkley is pushing for a start after scoring the winner off the bench in that game.
Cesar Azpilicueta will be back in at right-back, while Marcos Alonso is set to return at left-back.
Chelsea predicted XI to face West Ham (4-3-3): Kepa; Azpilicueta, Zouma, Rudiger, Alonso; Barkley, Kante, Kovacic; Willian, Giroud, Mount.