Ole Gunnar Solskjaer’s side have been buoyed by their 2-0 victory against Chelsea, pulling them to within just three points of the top four.
Odion Ighalo could make his full debut for the club, while Mason Greenwood is also likely to feature.
Brugge are nine points clear at the top of the Belgian Premier League, however, they have lost their star midfielder Sander Berge to Sheffield United.
Here is everything you need to know:
When is it?
The match kicks off at 17.55 at Jan Breydel Stadium on Thursday 20 February.
How can I watch it?
The game will be broadcast live on BT Sport 2.
Brugge: Mignolet, Mata, Kossounou, Mechele, Deli, Rits, Balanta, Vanaken, Bonaventure, Tau, De Cuyper
United: Romero, Dalot, Lindelof, Maguire, Shaw, Williams, Matic, Mata, Pereira, Lingard, Martial
Brugge – 15/8
Draw – 21/10
United – 7/5