The UK has recorded 214 coronavirus-related deaths and 39,329 cases in the latest 24-hour period.
The number of fatalities is a drop on the 262 reported on Tuesday - and close to the 217 reported last Wednesday.
A total of 142,338 people have now died with COVID-19 in the UK.
The number of cases reported on Wednesday is higher than the figures recorded on Tuesday (33,117) but lower than this time last week (41,299).
Meanwhile, an increase of 39,836 first vaccine doses means a total of 50,336,130 have been delivered in the UK.
Some 45,894,237 second doses have been delivered, an increase of 21,199.
A combined total of 10,920,416 booster and third doses have also been given, a day-on-day rise of 340,294.
Separate figures published by the Office for National Statistics (ONS) show there have been 167,367 deaths registered in the UK where COVID-19 was mentioned on the death certificate.
The highest number on a single day was 1,484 on 19 January.
The daily toll peaked at 1,461 during the first wave of the virus, on 8 April 2020.
A total of 859 deaths registered in England and Wales in the week ending 29 October mentioned COVID-19 on the death certificate - a rise of 8% on the previous week and the highest figure since the week to 24 September.
The ONS also released data indicating that the pandemic "appears to have had an indirect effect" on deaths in private homes.
"This could be because of a combination of factors which may include health service disruption, people choosing to stay away from healthcare settings or terminally ill people staying at home rather than being admitted to other settings for end-of-life care," said Sarah Caul, head of mortality analysis.
Heart disease, cancer and other causes are continuing to drive a large number of extra deaths in homes since the pandemic started, rather than COVID-19 itself, the ONS said.
Private homes are the only setting in England and Wales where deaths have been above average each month from January 2020 to June 2021, compared with before the pandemic.
Between January 2020 and June 2021, 27,048 men died due to heart disease in private homes - 18% above the pre-pandemic average.
The increase was 10% for women dying of heart disease in private homes, with 12,183 lives lost during the same period.