Sam Allardyce hinted he would make widespread changes but two of Palace's major attacking threats have made the cut.
The Eagles have boosted their survival hopes with wins over Chelsea, Arsenal and Liverpool in recent weeks and will be aiming to secure another scalp at Selhurst Park.
Palace are seven points clear of the drop zone and need just one more victory to surpass the magical 40-point mark of safety.
Crystal Palace XI: Hennessey, Ward, Kelly, Sakho, Schlupp, Milivojevic, Puncheon, McArthur, Zaha, Townsend, Benteke.
Crystal Palace subs: Speroni, Van Aanholt, Delaney, Cabaye, Sako, Flamini, Campbell.
Tottenham XI: Lloris (C), Walker, Dier, Alderweireld, Vertonghen, Davies, Wanyama, Dembele, Eriksen, Dele, Kane.
Tottenham subs: Lopez, Trippier, Wimmer, Sissoko, Nkoudou, Son, Janssen.
What they're saying
Sam Allardyce: "Some of the best results I've had in my long career as a manager in the Premier League given who we've beaten.
"The players have done a fantastic job but I just hope they don’t come off the gas and think we've done it."
Mauricio Pochettino: "We are ready again to compete, six games ahead to finish the season, big things to play for and a massive game against Palace.
"We hope to play well and get the three points."