It’s been over a year since the Briton was controversially denied by the judges after surviving a dramatic 12th round where he was seemingly knockout out cold by a vicious right hand.
Wilder is making the 11th defence of his title – with a win taking him past Muhammad Ali’s record – as the American looks to extend his record to 44 fights undefeated.
Ringwalks are expected at around 9pm Pacific Standard Time and 12am Eastern Time, with both heavyweights promising to deliver an early knockout.
Here’s everything you need to know:
When and where is the fight?
The fight takes place at the MGM Grand arena in Las Vegas on Saturday 22 February – or the early hours of Sunday morning for UK viewers.
What time does the fight start in the US?
The ring walks are expected at approximately 9pm PST or 12am EST.
How can I watch it and how much does it cost?
The fight will be broadcast live on BT Sport Box Office for £24.95. Fans can also stream the fight online via BT’s official website.
Who is on the undercard?
Charles Martin vs Gerald Washington (heavyweight)
Emanuel Navarrete vs Jeo Santisima (WBO World Super Bantamweight Title)
Amir Imam vs Javier Molina (welterweight)
Isaac Lowe vs Alberto Guevara (featherweight)
Subriel Matias vs Petros Ananyan (welterweight)
Sebastian Fundora vs Daniel Lewis (super welterweight)
Gabriel Flores Jr vs Matt Conway (lightweight)
Rolando Romero vs Arturs Ahmetovs (lightweight)
Vito Mielnicki Jr vs Corey Champion (welterweight)
What’s at stake?
Wilder is looking to make the 11th defence of his WBC World Heavyweight title and thereby surpassing Muhammad Ali’s record. The Ring Magazine title and Fury’s status as lineal champion are also up for grabs.
What are the odds?
Wilder: To win – 1/1, by KO – 11/10, on points – 11/1.
Fury: To win – 10/11, by KO – 5/1, on points – 13/8.
The impact of that final round 14 months ago has the potential to make or break Wilder. On one hand, the American has full confidence in his ability to knock Fury out, which could result in him looking for that loaded right hand much earlier in the contest. But on the other, the reigning champion could easily lose his game plan and give Fury the opportunity to demonstrate his superior boxing talent as well as offer the chances he claims he wants to knock Wilder out. Either way, the chances of a Wilder points win looks even slimmer than December 2018, and with Fury battle-hardened this time around, the Briton looks set for an unlikely points win – which proved the downfall of Wladimir Klitschko all those years ago.