The awards, which are in their 25th year, celebrate achievements across the arts in categories including music, theatre, art, literature, comedy and opera.
Popstar Lipa took home the pop award for her chart-topping album Future Nostalgia, described by the organisers as a “sensationally popular album which received critical acclaim across the board.”
It comes after she took home the trophy for best female solo artist at the Brit Awards in May when she used her acceptance speech to call for an NHS pay rise.
Sir Sam won the individual award for innovation in the arts during the pandemic for his work on a fund to help workers in the theatre industry.
Meanwhile Perry was handed the outstanding achievement award.
Michaela Coel’s I May Destroy You was named the winner in the TV drama category, while Hamnet by Maggie O’Farrell won the literature prize.
Rocks, which follows the story of a girl who is abandoned by her mother in east London, won the film prize.
Normal People actress Daisy Edgar-Jones and Coronation Street star Katherine Kelly were pictured on the red carpet.
Other stars to grace the red carpet included Bafta winning actor Martin Freeman, children’s author Dame Jacqueline Wilson and opera singer Carly Paoli.
Broadcaster Melvyn Bragg presented the awards.
“The arts have kept up their reputation for excellence in difficult circumstances,” he said.
“Without question they are world-class, as these awards show.”
The ceremony will air on Sky Arts at 9pm on Thursday.
Phil Edgar-Jones, director of Sky Arts, said: “We’re excited to be carefully inviting Britain’s best and brightest arts practitioners back to the South Bank Sky Arts Awards in its 25th year.
“Despite the ravages of the pandemic, great art continues to thrive against all odds and, more than ever, we want to celebrate all the joy the creative industries bring.”