Eddie Jones’s shadow side scored 10 tries with two from Joe Cokanasiga, another from Ellis Genge and a penalty try adding to Newcastle duo Radwan and Blamire ‘s triples.
Marcus Smith, who was called up to the Lions during the match, kicked nine conversions.
Canada were playing just their second match since the 2019 World Cup, having being thumped 68-12 by Wales last weekend.
England, without around 20 players on British and Irish Lions duty or rested, were on top throughout and gave first caps to four players, following the 12 debutants in last week's win over the United States.
Flyhalf Marcus Smith landed all nine of his conversion attempts and his day got even better when he discovered he has been summoned to join the Lions in South Africa.
Additional reporting by Reuters.