Saka came back into Southgate’s starting XI as Denmark were beaten 2-1 in the semi-final, assisting the equaliser which was turned into his own net by Simon Kjaer, but Gareth Southgate has sacrificed an attacker for an extra defender.
Phil Foden was an injury doubt after he missed England’s final training session on Saturday and he is one of the unlucky three players from the squad to miss out, along with Ben Chilwell and Ben White.
Jack Grealish and Jadon Sancho will again be on the bench, along with Saka despite a fine display against Denmark.
Jordan Henderson will also be watching on from the sidelines as Kalvin Phillips and Declan Rice keep their spots in central midfield, with Mason Mount supporting Raheem Sterling and Harry Kane.
Here is how we England will line up against Italy at Wembley...
England starting lineup
England XI (3-4-3): Pickford; Walker, Stones, Maguire; Trippier, Phillips, Rice, Shaw; Mount, Kane, Sterling
Goalkeepers: Sam Johnstone, Jordan Pickford, Aaron Ramsdale*
Defenders: Ben Chilwell, Conor Coady, Reece James, Harry Maguire, Tyrone Mings, Luke Shaw, John Stones, Kieran Trippier, Kyle Walker, Ben White
Midfielders: Jude Bellingham, Jordan Henderson, Mason Mount, Kalvin Phillips, Declan Rice
Forwards: Dominic Calvert-Lewin, Phil Foden, Jack Grealish, Harry Kane, Marcus Rashford, Bukayo Saka, Jadon Sancho, Raheem Sterling
* Replaces Dean Henderson, who withdrew due to injury
England have no suspensions to contend with.