With the Premier League title race on pause due to the FA Cup semi-finals, the action is further down the table this weekend.
West Ham host Everton in one of four 3pm Saturday kick-offs, hoping to climb further up the table after steering clear of relegation trouble in recent weeks.
Romelu Lukaku, though, will be confident of extending his lead in the race to win the Golden Boot having scored in each of his previous nine games against West Ham.
Crystal Palace head to Anfield to face Liverpool on Sunday looking to cause another shock after recent wins over Chelsea and Arsenal.
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Palace will have to do without loanee Mamadou Sakho, who is ineligible to face his parent club. Any positive result will all but secure Palace's Premier League status for another year.
Liverpool, though, will know a win will close the gap on second-placed Tottenham to two points though having played two more games.
Manchester United will be desperate for a win to keep their top-four hopes alive, playing their game in hand on fourth-placed Manchester City when they travel to Burnley on Sunday.
Elsewhere, Hull City host Watford while Swansea entertain Stoke City in two crunch games in the relegation battle. Middlesbrough, who look all but gone, travel to Bournemouth.