Tottenham beat Bournemouth 4-0 on Saturday to cut the Blues' title lead at the top of the table to just four points, with Mousa Dembele, Heung-min Son, Harry Kane and Vincent Janssen were all on target.
Mauricio Pochettino is adamant the title pressure will now be on for Antonio Conte's side, with Tottenham themselves stepping up by winning seven Premier League games in a row for the first time in their history.
Meanwhile, Manchester City beat Southampton 3-0 in Saturday's evening kick-off to dent Arsenal's top-four hopes.
Liverpool secured a crucial 1-0 win at West Brom to move third in the table on Sunday, meaning Arsenal need to make up a 10-point gap to the Champions League places - with two games in hand - by the time they kick-off at the Riverside Stadium on Monday evening.
Elsewhere, Crystal Palace fought back from two goals down to secure a creditable 2-2 draw with champions Leicester.
Sam Allardyce's side are seven points clear of the drop zone and - if their form continues - look set to retain their top-flight status.
West Ham squandered a lead deep into injury time at Sunderland, with Fabio Borini's equaliser keeping the Black Cats' slender hopes of survival alive.
Everton climbed to fifth place courtesy of a 3-1 victory over Burnley but the majority of the Toffees' rivals still have crucial games in hand.
Meanwhile, Stoke eased past Hull while Watford cemented their position in the top half of the table with a 1-0 victory over relegation-threatened Swansea.