Jurgen Klopp's men, sitting in third, are now nine points clear of Arsenal in sixth place though have played three games more.
Later in the day, Chelsea and Tottenham kick-off at the same time for the first time this season since gameweek two as the Blues look to further tighten their grip on the Premier League title.
Antonio Conte & Co. still hold a 10-point gap over their nearest rivals, with Spurs now two better off than City in fourth.
EPL | The Premier League table after 30 matches
The Blues hosts Crystal Palace, while Spurs make the trip to Burnley hoping to become just the fourth of 15 visiting teams to win at Turf Moor this season.
Arsenal begin a Premier League weekend in sixth place for the first time since September following a 3-1 loss at West Brom last time out. They welcome City to the Emirates Stadium on Sunday.
Down the other end of the table, Palace will be hoping to take anything away from Stamford Bridge despite three wins, and three clean sheets, on the bounce.
West Ham could do their London rivals a favour when they travel to relegation candidates Hull City. Palace are currently four points clear of the 18th-placed Tigers having played a game less.
Finally, bottom-of-the-pile Sunderland will surely have earmarked Saturday's trip to a struggling Watford for possible points in their ever-faltering battle against relegation.