Spurs moved to within four points of Antonio Conte's side after goals from Dele Alli, Eric Dier and a double from Heung-min Son swept aside an injury-hit Watford side in the lunchtime kick-off.
Harry Kane made his return from injury in the comprehensive win as the England man was introduced in the second period, while Tottenham's goal difference now has a healthy look to it as the title race reaches its business end.
Mauricio Pochettino's side now boast a goal difference of +42 - four goals better than Chelsea's, who will look to re-establish their seven-point advantage when they face Bournemouth in Saturday's evening kick-off.
EPL | The Premier League table after 32 matches
Elsewhere, West Ham won a crunch relegation clash at London Stadium as they beat Swansea 1-0 courtesy of a goal from Cheikhou Kouyate.
Liverpool have made life harder for Arsenal and Manchester United in the top-four battle as they fought back from a goal down to beat Stoke 2-1 at the bet365 Stadium, with Roberto Firmino and Philippe Coutinho scoring off the bench in the second half.
Manchester City kept up the fight for Champions League qualification as they beat Hull 3-1, while relegation rivals Middlesbrough and Burnley saw out a 0-0 draw at the Riverside Stadium. Elsewhere, Southampton beat West Brom 1-0 in the battle for a top-eight finish.
Crystal Palace host Arsenal in Monday's game at Selhurst Park.