Antonio Conte & Co. still hold a 10-point gap over their nearest rivals, with Spurs now two better off than third-placed Manchester City in the race for the runners-up spot.
The Blues hosts Crystal Palace, while Spurs make the trip to Burnley hoping to become just the fourth of 15 visiting teams to win at Turf Moor this season.
Arsenal begin a Premier League weekend in sixth place for the first time since September following a 3-1 loss at West Brom last time out. They welcome City to the Emirates Stadium on Sunday.
EPL | The Premier League table after 29 matches
Liverpool, meanwhile, will be hoping to consolidate fourth place when they host Everton in the early Saturday kick-off, having not lost to their Merseyside rivals in six and a half years.
Down the other end of the table, Palace will be hoping to take anything away from Stamford Bridge despite three wins, and three clean sheets, on the bounce.
West Ham could do their London rivals a favour when they travel to relegation candidates Hull City. Palace are currently four points clear of the 18th-placed Tigers having played a game less.
Finally, bottom-of-the-pile Sunderland will surely have earmarked Saturday's trip to a struggling Watford for possible points in their ever-faltering battle against relegation.