Antonio Conte's Blues are four points clear at the top of the table after Tottenham's 1-0 win at Crystal Palace, and head to Goodison Park knowing another win will put them one step closer to the title.
But Everton boss Ronald Koeman will be confident of troubling Chelsea given that he boasts the Premier League's top scorer Lukaku.
Chelsea have targeted their former striker for a Stamford Bridge return this summer, but the Belgian's focus this weekend will be on adding to his 24 league goals this season and putting a dent in Conte's title ambitions.
Scroll down for Standard Sport's comprehensive preview...
Everton host Chelsea at Goodison with kick-off scheduled for 2:05pm on Sunday, April 30.
TV AND LIVE ONLINE COVERAGE
The match will be televised live on Sky Sports 1, with coverage starting from 1pm. Alternatively, you can follow all the build-up and action from 1pm with Standard Sport’s London Football live blog.
Can't see the live blog? Click here for the desktop version.
Everton have Enner Valencia available for Sunday after the striker was ineligible to face parent club West Ham last week.
None of the Toffees' injured stars are ready to return, however. Midfielder Muhamed Besic is building up his fitness after a year out with a serious knee injury but James McCarthy (hamstring), Ramiro Funes Mori, Yannick Bolasie (both knee), Seamus Coleman (broken leg) and Aaron Lennon all remain sidelined.
Provisional squad: Robles, Holgate, Williams, Jagielka, Baines, Schneiderlin, Gueye, Barkley, Davies, Mirallas, Lukaku, Stekelenburg, Pennington, Kenny, Barry, Williams, Calvert-Lewin, Lookman, Kone, Valencia.
Antonio Conte, meanwhile, can pick from a full strength squad and the Blues manager is expected to continue with his tried and tested regulars as his side edge ever close to the Premier League title.
That means the likes of Eden Hazard and Diego Costa should lead Chelsea's challenge at Goodison Park.
Provisional squad: Courtois, Begovic, Fabregas, Zouma, Alonso, Kante, Hazard, Loftus-Cheek, Moses, Pedro, Costa, Matic, Willian, Batshuayi, Cahill, Terry, Azpilicueta, Chalobah, Luiz, Eduardo, Aina, Ake.
Everton starting XI: Stekelenburg, Holgate, Jagielka, Williams, Baines, Gueye, Schneiderlin, Davies, Barkley, Lukaku, Mirallas
Chelsea starting XI: Courtois; Azpilicueta, Luiz, Cahill; Moses, Kante, Matic, Alonso; Fabregas, Hazard; Costa
BETTING ODDS (via 888 Sport)
- Everton to win: 27/10
- Chelsea to win: 26/25
- Draw: 13/5
Click here to place a bet. Odds correct as of April 28 at 4pm.