Antonio Conte's Blues are four points clear at the top of the table after Tottenham's 1-0 win at Crystal Palace, and head to Goodison Park knowing another win will put them one step closer to the title.
But Everton boss Ronald Koeman will be confident of troubling Chelsea given that he boasts the Premier League's top scorer Lukaku.
Chelsea have targeted their former striker for a Stamford Bridge return this summer, but the Belgian's focus this weekend will be on adding to his 24 league goals this season and putting a dent in Conte's title ambitions.
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Everton host Chelsea at Goodison with kick-off scheduled for 2:05pm on Sunday, April 30.
TV AND LIVE ONLINE COVERAGE
The match will be televised live on Sky Sports 1, with coverage starting from 1pm. Alternatively, you can follow all the build-up and action from 1pm with Standard Sport’s London Football live blog.
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Gary Cahill made a match-winning return after a short stay in hospital with a goal in the midweek victory over Southampton, boosting Conte's defensive options.
The Italian coach has a fully fit squad to choose from as the season enters its climax, with the likes of Willian and Pedro pushing for starts after missing out against the Saints.
The one area of concern for Conte will be his defence, with the Chelsea back line breached twice against both Tottenham and Southampton.
Everton starting XI: Stekelenburg, Holgate, Jagielka, Williams, Baines, Gueye, Schneiderlin, Davies, Barkley, Lukaku, Mirallas
Chelsea starting XI: Courtois; Azpilicueta, Luiz, Cahill; Moses, Kante, Matic, Alonso; Fabregas, Hazard; Costa
BETTING ODDS (via 888 Sport)
- Everton to win: 13/5
- Chelsea to win: 26/25
- Draw: 13/5
Click here to place a bet. Odds correct as of April 26 at 4pm.