The eight-round contest takes place at Hard Rock Stadium in Miami Gardens, with around 25,000 fans expected to be in attendance.
It marks the third return to the ring for Mayweather since his initial retirement in 2015, having beaten UFC star Conor McGregor in the so-called ‘Money Fight’ in 2017 and also Japanese kickboxer Tenshin Nasukawa in Tokyo the following year.
Despite the huge size difference between the pair, the five-weight world champion will be the overwhelming favourite again tonight, though will have to record a knockout or a stoppage to secure victory with no winner being declared after the fight is over.
Internet personality Paul has only one professional fight to his name to date - a defeat to fellow YouTuber KSI in Los Angeles in November 2019.
How to watch Mayweather vs Logan Paul
TV channel: Tonight’s Floyd Mayweather vs Logan Paul showdown is being broadcast live on Sky Sports Box Office in the UK, with the main event not starting until at least 3am BST in the early hours of Monday morning.
Live stream: Those that have bought the fight in the UK can also watch the action live online via the Sky Sports Box Office website or app.
Mayweather vs Logan Paul price
The event is priced at £16.95 on Sky Sports Box Office.