Kane made his first start in five weeks after ankle ligament problems as he returned to Mauricio Pochettino's XI to score the third of Spurs' four goals in a 4-0 win against Bournemouth.
The England international closed the gap on Lukaku to three goals, but the Belgian extended his lead to four once again as he struck in Everton's 3-1 victory over Hull at Goodison Park.
Despite another impressive performance from Dele Alli, the only midfielder in the top seven, the 21-year-old Spurs star failed to find the net against the Cherries as he stays on 16 goals.
Sergio Aguero then wrapped up Manchester City's win over Southampton on the south coast to move level with Zlatan Ibrahimovic and Diego Costa.
Costa and Ibrahimovic face off on Sunday as Manchester United host Chelsea at Old Trafford, while Alexis Sanchez has 18 goals but can add to his tally when Arsenal travel to Middlesbrough on Monday night.
Golden Boot odds (via 888Sport)
- Lukaku: 1/4
- Kane: 6/1
- Sanchez: 25/1
- Costa: 20/1
- Aguero: 20/1
- Ibrahimovic: 20/1
- Alli: 80/1