It is understood Matt Hancock will rule on the status of the Fox bid for Sky, the owner of Sky News, which has been delayed by a regulatory process to determine if a deal would give the US company too much influence over UK media.
Mr Hancock, who is due to make his statement at around 1.30pm, has until 13 June to consider a final report on the issue from the Competition and Markets Authority (CMA), which had recommended in January that the proposed £17.5bn deal was blocked.
Fox has since offered a series of remedies to address the watchdog's concerns - including the immediate sale of Sky News to Disney on completion of a takeover of Sky.
The takeover saga is further complicated by other factors, including the fact that Disney has agreed a separate deal to buy Fox's entertainment assets, including Sky.
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Sky's independent directors withdrew their recommendation for the Fox offer to shareholders after Comcast (Swiss: CMCSA.SW - news) , the owner of Universal Pictures, confirmed a bid for Sky of £22.5bn.
Mr Hancock has already indicated he is minded to allow a takeover by Comcast - given its minimal presence in the UK media landscape.
It is understood he will also give a ruling on Comcast's interest in Sky.
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The secretary of state has what is known as a quasi judicial role following a regulatory investigation of this sort, in that he ultimately decides the fate of any bid.
Mr Hancock could decide there are no concerns or allow a potential deal to go ahead subject to certain conditions being met.
He could also potentially request further information and delay a ruling to a later date.