The 16-year-old environmental activist is one of five people who will take over the BBC Radio 4 show.
Others include Supreme Court president Lady Hale, who delivered the ruling that Boris Johnson’s decision to suspend Parliament was unlawful.
Each programme will include an interview with the guest editor.
Nobel Peace Prize nominee Ms Thunberg, who has spearheaded a global movement and school strikes around the world, will speak to leading climate change figures and hear from indigenous, frontline activists during her guest edit spot.
Lady Hale gives the programme a tour of the Supreme Court and has asked Today to explore the issue of coercive control – extreme psychological and emotional abuse.
Spoken word artist George The Poet will report from Uganda and explore issues around identity.
Turner Prize winner Mr Perry will examine stereotypes and Mr Moore, former editor of The Daily Telegraph, will focus on freedom of expression.
They will each guest edit the programme between December 26 and 31.
The Today guest editors are part of the BBC Radio and Sounds Christmas line up, which is fully unveiled on Monday.
Additional reporting by agencies