The Salford rock band - fronted by Shaun Ryder and Bez - are due to perform in the Big Top at Seaclose Park.
The Step on and Kinky Afro group are due on stage from 9.55pm.
Also appearing in the Big Top tonight is M People's Heather Small. The Moving On Up, One Night In Heaven, and Search For The Hero star returns after her 2019 appearance.
Tonight, she's due on stage from about 9pm.
From 7.25pm, check out The Compozers, while Rick Parfitt Jnr, son of the Status Quo frontman, who played the Isle of Wight Festival in 2016, before his death later that year, will be the first act of the weekend.
He is due on stage, at 6pm.
Be prepared for a changes to the usual entrances to the site, because Main Stage does not open until tomorrow (Friday).
Heather Small in the Big Top, in 2019.